Tentative Lecture schedule "Biochemistry of Medicinals I"

Part 2 – Nucleic Acids Phar 6151

Instructor: Dr. Natalia Tretyakova, Ph.D. «hyperlink "mailto:[email protected]" »6-3432

11-05 Introduction. DNA structure. Double helix, A, B, Z –form of DNA. Biophysical properties of DNA.

11-07 DNA topology. Supercoiling. Enzymes that change DNA: endonucleases, exonucleases, topoisomerases.

11-09  DNA replication. Polymerization reaction. E. Coli Pol I

11-12 DNA replication (continued). Initiation, elongation, and termination.

11-14 DNA repair. Mutations and cancer.

11-16 Transcription.

11-19 RNA structure. RNA synthesis in prokaryotes. RNA Pol. I.

11-21 RNA synthesis in eukaryotes. Transcription factors.

11-23 No class

11-26 Post-transcriptional modifications in eukaryotes. Review of DNA

11-28 Exam I. Nucleic acids. DNA structure and synthesis. Transcription. mRNA.

11-30 RNA splicing.

12-03 Translation. Genetic code. tRNA.

12-05  tRNA activation

12-07  Codon-anticodon interactions

12-10 Protein synthesis – translation

12-12 Protein synthesis – translocation. Drugs inhibiting protein synthesis

12-14 Review of tRNA, Protein synthesis. Course evaluation

12-17 Exam II. tRNA . Protein synthesis.